Why the study?
Myocardial fibrosis is a common pathological process in cardiac diseases that impairs cardiac function and causes sudden death, but effective and safe therapies are currently limited.
Design
Review
Key result
Natural compounds can modulate multiple profibrotic signaling pathways to improve myocardial fibrosis, though comprehensive data on their clinical efficacy and long-term safety are still lacking.
Authors
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May offer adjunctive options for MF with limited therapies; extends preclinical signals but requires confirmatory RCTs.
Natural compounds show therapeutic potential for myocardial fibrosis by regulating profibrotic signaling pathways, though clinical translation requires further pharmacokinetic and clinical trial data.
Li et al. (2026) conducted a review in Myocardial fibrosis. Natural compounds was evaluated. Natural compounds can modulate multiple profibrotic signaling pathways to improve myocardial fibrosis, though comprehensive data on their clinical efficacy and long-term safety are still lacking.