What question did this study set out to answer?

This study aims to enhance the delivery and efficacy of curcumin, a natural anticancer compound, by using PLGA and PLGA-PEG nanoparticles.

May 22, 2026Open Access

Formulation, Characterisation, and In Vitro Anticancer Evaluation of Curcumin-Loaded PLGA and PLGA-PEG Nanoparticles Against MCF-7 Breast Cancer Cells

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This study aims to enhance the delivery and efficacy of curcumin, a natural anticancer compound, by using PLGA and PLGA-PEG nanoparticles.
Prepared curcumin-loaded PLGA and PLGA-PEG nanoparticles using nanoprecipitation.
Characterized nanoparticles via DLS, zeta potential, and encapsulation efficiency measurements.
Assessed in vitro anticancer efficacy against MCF-7 cells using MTT assay and flow cytometry.
PLGA-PEG nanoparticles showed an IC₅₀ of 41.2 µg/mL against MCF-7 cells, significantly lower than the 108.4 µg/mL for free curcumin.
Cumulative drug release was 94.1% at pH 5.0 versus 81.4% at pH 7.4 after 72 hours.
A total of 63.0% apoptotic cells were observed compared to only 19.4% in the untreated control.

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Implication

Randomized trial evaluates curcumin's enhanced anticancer effects in MCF-7 cells, indicating improved therapeutic potential through nanoparticle delivery.

Cite This Study

Rajiv Mehta Dhruvika Patel (2026) studied this question.

synapsesocial.com/papers/6a0ff3ffd674f7c03778cff2 https://doi.org/10.5281/zenodo.20305550

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Implication

Randomized trial evaluates curcumin's enhanced anticancer effects in MCF-7 cells, indicating improved therapeutic potential through nanoparticle delivery.

Formulation, Characterisation, and In Vitro Anticancer Evaluation of Curcumin-Loaded PLGA and PLGA-PEG Nanoparticles Against MCF-7 Breast Cancer Cells

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Discussion

Implication

Cite This Study

Formulation, Characterisation, and In Vitro Anticancer Evaluation of Curcumin-Loaded PLGA and PLGA-PEG Nanoparticles Against MCF-7 Breast Cancer Cells

Key Points

Discussion

Implication

Cite This Study

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