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May 20, 2026Archives of Physiology and Biochemistry

The role of SOST protein (osteocalcin) regulatory mechanism in enhancing bone strength during endurance training: Wnt/β-catenin pathway

Guizhen Chen Yu Yang Y. Qin Dongyi Wei

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Key Points

This study aims to investigate how the regulation of SOST protein enhances bone strength during endurance training.
Animal model using 8-week-old male C57BL/6 mice divided into five groups: control, sham, endurance training, SOST gene knockout, and SOST KO with endurance training.
Endurance training and SOST gene knockout interventions were employed to assess their effects on bone strength.
Endurance training significantly improves bone strength (p < 0.05).
Bone resorption markers CTX and TRACP-5b did not show significant changes.

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Implication

Investigates SOST protein's impact on bone strength during endurance training, suggesting a novel therapeutic approach.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3ffd674f7c03778d0b3 https://doi.org/10.1080/13813455.2026.2675975

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