Recent advances of piperine and its derivatives as potential anticancer agents

Qi-Hua Yu; Zhiyan Liu; Jiazheng Liu; Li-Ping Bai

doi:10.1039/d6md00223d

January 1, 2026RSC Medicinal Chemistry

Recent advances of piperine and its derivatives as potential anticancer agents

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Key Points

This research investigates the anticancer potential of piperine and its derivatives derived from Piper nigrum.
Evaluated biological activities of piperine and its derivatives in cancer cell lines.
Analyzed the effects on various cancer pathways using in vitro and in vivo models.
Assessed the potential therapeutic implications of these phytochemicals in cancer treatment.
Piperine and its derivatives showed significant inhibition of tumor growth in vitro and in vivo (exact rates not provided).
Induced apoptosis (programmed cell death) in cancer cells with a notable increase in cancer biomarkers (specific metrics not provided).
Highlighted potential synergy with existing anticancer therapies, suggesting improved treatment strategies.

Implication

Evaluates effects of piperine and derivatives on cancer pathways, suggesting therapeutic potential.

Abstract

Piperine, a crucial ingredient of the plant Piper nigrum, exhibits a broad spectrum of biological activities and has attracted interest as a potential anticancer agent. With a low yield in...

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Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff412d674f7c03778d233 https://doi.org/10.1039/d6md00223d

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Recent advances of piperine and its derivatives as potential anticancer agents

Key Points

Implication

Abstract

Discussion

Cite This Study

Recent advances of piperine and its derivatives as potential anticancer agents

Key Points

Implication

Abstract

Discussion

Cite This Study

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