The Worst of Both Worlds: A Case Series of Adenosquamous Carcinoma of the Esophagus

Esophageal adenosquamous carcinoma (EASC) is a rare, aggressive malignancy with histologic features of both squamous cell carcinoma and adenocarcinoma. We report a case series of 2 patients with EASC. The first case involves a middle-aged woman with traditional risk factors, including a 46-pack-year smoking history, frequent alcohol use, and long-segment Barrett's esophagus, managed with neoadjuvant chemoradiation, esophagectomy with lymphadenectomy, and radiofrequency ablation. The second case involves a young man without traditional risk factors who presented with advanced disease. These cases highlight the diagnostic and therapeutic challenges of EASC and the need for comprehensive management and vigilant surveillance.