What question did this study set out to answer?

This review aims to clarify the etiology and pathogenesis of idiopathic achalasia, focusing on contributing factors.

Idiopathic achalasia: unraveling the etiology and pathogenesis of an inflammatory disease

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Review elucidates the causes and mechanisms behind idiopathic achalasia, highlighting genetic and environmental factors.

This review aims to clarify the etiology and pathogenesis of idiopathic achalasia, focusing on contributing factors.
Reviewed existing literature on viral infections, autoimmunity, and genetic predisposition related to achalasia.
Explored the roles of psychological factors and gut microbiota in the disease's development.
Assessed the impact of chronic inflammation on esophageal motility disorders.
Identified initial esophageal injury from viral infection as a potential trigger for inflammation.
Chronic inflammation linked to the destruction of inhibitory myenteric neurons and subsequent achalasia symptoms.
Emphasized the importance of genetic, psychological, and microbiota influences in the disease's pathogenesis.

Wei et al. (2026) studied this question.

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