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May 22, 2026Pulmonary TherapyOpen Access

Peripheral Blood Inflammatory Markers and Immune Cell Profiles in Smokers With and Without COPD

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Cross-sectional study compares blood inflammation markers in smokers and non-smokers, highlighting implications for COPD management.

This study aims to compare inflammatory markers and immune cell profiles in smokers with and without COPD and non-smokers.
Cross-sectional design with 80 participants divided into four groups: non-smokers, smokers with normal lung function, current smokers with COPD, and ex-smokers with COPD.
Blood samples collected to measure total white cell count, leukocyte differentials, C-reactive protein, and erythrocyte sedimentation rate.
Lung function parameters were assessed and correlated with blood markers.
Smokers, including those with normal lung function, exhibited higher white blood cell counts and inflammatory markers compared to non-smokers (p < 0.05).
Higher eosinophil levels were observed in ex-smokers with COPD compared to current smokers (p < 0.05).
In COPD, increased blood inflammatory cell counts correlated with poorer lung function (p < 0.05).

Lu et al. (2026) studied this question.

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