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January 1, 2026RSC AdvancesOpen Access

Development of green purification process for piperazine-type drugs: a case study of quetiapine process development

Wenfeng Huang Youhu Wang Hanrong Liu Hui Li Qiuxiang Yin

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Key Points

The aim is to develop an environmentally friendly purification process for piperazine-type drugs, focusing on quetiapine.
Utilized ACD software to predict pKa values of intermediates and impurities.
Conducted six batches of hundred-kilogram scale experiments to ensure reproducibility.
Demonstrated good reproducibility across six production batches.
Successfully identified optimal pH range for the purification process.

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Implication

Demonstrates effective green purification of quetiapine drugs, highlighting sustainability benefits.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff43fd674f7c03778d7c4 https://doi.org/10.1039/d6ra00670a

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