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May 22, 2026Journal of Addiction Medicine

Benzodiazepine Tapering: Evidence Limitations and Research Recommendations

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Authors

BKBethea A. KleykampADAmanda DevotoDLDawn Lindsay

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Overview

This systematic review highlights evidence limitations on benzodiazepine tapering, suggesting key research directions to improve patient safety and outcomes.

Key Points

  • This research aims to evaluate the current evidence on benzodiazepine tapering and to propose research recommendations for future studies.
  • Conducted a systematic review as part of developing benzodiazepine tapering guidelines.
  • Identified research gaps through feedback during guideline development.
  • Proposed recommendations for pragmatic trials and patient-centered approaches.
  • Identified significant variability in tapering strategies and outcome measures.
  • Found methodological limitations and a lack of safety and patient-reported outcomes in existing literature.
  • Recommended novel research techniques including comparative effectiveness trials and shared decision-making strategies.

Cite This Study

Kleykamp et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff43fd674f7c03778d7f2https://doi.org/10.1097/adm.0000000000001715
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  1. 1Benzodiazepine receptor agonist deprescribing principles for long-term use and dependence: modified Delphi recommendations from a multi-disciplinary expert panel2026
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  3. 3Inpatient Management of Benzodiazepine Withdrawal: A Narrative Review of a Systematic, Individualized Taper Design2026
  4. 4Benzodiazepine Tapering: A Marathon, Not a Sprint2026
  5. 5Toward clarifying ASAM’s inpatient and residential benzodiazepine tapering recommendations2026