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May 20, 2026Scientific ReportsOpen Access

Curcumin-Dragon’s blood-chitosan nanosuspension for dual forensic detection

Adel Al Fatease B. Nagashubha Umme Hani Ali H. Alamri Kiran Sai Maccha Awaji Y. Safhi Fahad AlQahtani Sree Lakshmi Mallam Sowmya Vallabhi Yashmeen Banu Shaik Veeresh Chakali

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Key Points

This study aims to develop a biocompatible nanosuspension for improved forensic identification of latent fingerprints and bloodstains.
Nanosuspension synthesized using ionic gelation method with curcumin and Dragon’s blood in chitosan matrix.
Formulation optimized using Box-Behnken Design assessing chitosan, curcumin, and TPP concentrations.
Forensic efficacy evaluated through fluorescence imaging and ridge detail analysis on various substrates.
Optimized formulation achieved an average particle size of 220.5 ± 5.4 nm and encapsulation efficiency of 85.2 ± 3.1%.
The nanosuspension showed a ridge contrast ratio of 4.2 ± 0.3 versus 2.1 ± 0.4 for standard powders, indicating superior performance.
Fluorescent visualization enabled detection of fingerprints up to the 5th depletion with strong binding affinity to hemoglobin confirmed by molecular docking (8.2 kcal/mol).

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Implication

Investigates dual forensic function of a novel nanosuspension, suggesting enhanced evidence visualization.

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Cite This Study

Fatease et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff43fd674f7c03778d81b https://doi.org/10.1038/s41598-026-51407-z

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