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November 20, 2025Scientific ReportsOpen Access

Formulation and evaluation of taste-masked curcumin nanoparticles for improved antioxidant and anticancer efficacy

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Authors

MAMulham AlfatamaZRZalilawati Mat RashidOHOmar A. Harasstani

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Overview

Formulating nanoparticles enhanced palatability and therapeutic efficacy of curcumin, implying potential food and pharmaceutical applications.

Key Points

  • This research aims to improve the delivery and effectiveness of curcumin through nanoparticle encapsulation.
  • Developed alginate-based nanoparticles with and without chitosan coating for curcumin encapsulation.
  • Characterized particle sizes, zeta potentials, and encapsulation efficiencies of formulations.
  • Conducted FTIR analysis to confirm successful curcumin encapsulation.
  • Chitosan-coated nanoparticles showed enhanced antioxidant activity and palatability.
  • CANPs-Cs formulation led to a significant reduction in curcumin release in artificial saliva compared to uncoated nanoparticles.
  • Both formulations demonstrated strong cytotoxic effects against colon cancer cells, maintaining therapeutic efficacy.

Cite This Study

Alfatama et al. (2025) studied this question.

synapsesocial.com/papers/6924f074c0ce034ddc34fb4chttps://doi.org/10.1038/s41598-025-25022-3
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