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June 20, 2026International Journal of Nanoscience

Polymer-Stabilized Nanocurcumin as a Functional Nanomaterial: Enhanced Physicochemical Properties, Keap1 Binding and Antioxidant Performance

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Authors

ATAshish TiwariSSSnigdha SiddhBTBalram Tripathi

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Overview

Randomized trial shows enhanced antioxidant performance of polymer-stabilized nanocurcumin, indicating improved therapeutic potential.

Key Points

  • The aim is to enhance the physicochemical properties and functional performance of curcumin using polymer stabilization.
  • Synthesized polyvinylpyrrolidone coated nanocurcumin (PVP–NCur) via a modified solvent–antisolvent precipitation method.
  • Conducted molecular docking with the Keap1 Kelch domain to assess binding affinity.
  • Employed several antioxidant assays (ABTS, CUPRAC, hydroxyl, superoxide) for functional validation.
  • PVP–NCur achieved a drug loading efficiency of 64.7% and sustained release of approximately 76% after 48 hours (R^2 = 0.9913).
  • Binding affinity of PVP–curcumin complex improved to -9.7 kcal/mol compared to free curcumin at -9.0 kcal/mol.
  • Antioxidant activity of PVP–NCur was significantly higher than that of native curcumin in various scavenging assays.

Cite This Study

Tiwari et al. (2026) studied this question.

synapsesocial.com/papers/6a363172db0793dc1a53855dhttps://doi.org/10.1142/s0219581x26400041
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