Magnetic‐Field‐Driven Precision Fabrication of Multifunctional Microgels for Biomedical Applications

The fabrication of monodisperse microgels has achieved considerable success and has transformed many fields. However, conventional methods typically rely on external shear forces, interfacial perturbations, or toxic solvents, which restrict their application flexibility. This study presents a novel magnetic‐field‐actuated strategy for fabricating uniform microgels (300–900 µm) with tunable morphologies, including microspheres and microfibers, bypassing the need for external shear forces, interfacial perturbations, or toxic solvents. By integrating superparamagnetic iron oxide nanoparticles (SPIONs) into hydrogel precursors, internal magnetic stress gradients induce self‐driven droplet segmentation, enabling precise control over particle size and structure with high‐throughput production and exceptional uniformity. These biocompatible microgels exhibit robust magnetic responsiveness, facilitating precise positioning and occlusion in vascular embolism models and enhancing toxin clearance in hemodialysis by three to four times through turbulence induced by magnetically driven rotation. This magnetically programmable platform merges microgel synthesis and functionalization, offering a versatile class of carriers with adaptable structures for regenerative medicine and precision medicine applications.