What question did this study set out to answer?

Map regional and transmural blood flow distribution across the left ventricle following acute coronary artery occlusion using radioactive microspheres.

May 1, 1973Cardiovascular Research

Mapping of left ventricular blood flow with radioactive microspheres in experimental coronary artery occlusion

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Population

Nine dogs with experimental acute coronary artery occlusion

Comparison

Mapping of left ventricular blood flow with… vs Non-ischaemic myocardium (internal control)

Design

Preclinical

Follow-up

30-60 min

Authors

LBLewis C. BeckerCardiac Imaging RFRui Cruz FerreiraElectrophysiology MTMike ThomasEmory University

Discussion

Member takes

Implication

Highlights subendocardial vulnerability in experimental ischemia; leaves open translation to human coronary syndromes.

Key Points

Map regional and transmural blood flow distribution across the left ventricle following acute coronary artery occlusion using radioactive microspheres.
Induced acute coronary artery occlusion in nine canine models (N=9).
Administered radioactive microspheres 30 to 60 minutes post-occlusion to measure regional and transmural myocardial blood flow.
Perfusion was markedly reduced at the center of the ischemic region and moderately reduced at the periphery, while flow increased above normal levels in adjacent non-ischemic myocardium.
Blood flow was distributed uniformly across the ventricular wall in non-ischemic zones, but ischemic tissue exhibited a disproportionate flow reduction in the inner half of the wall.

Structured PICO

Population

Nine dogs with experimental acute coronary artery occlusion

Intervention

Mapping of left ventricular blood flow with radioactive microspheres

Comparator

Non-ischaemic myocardium (internal control)

Outcome

Pattern of regional left ventricular blood flowsurrogate

Experimental coronary occlusion in dogs demonstrates a gradient of ischemia with disproportionate reduction in blood flow to the subendocardium.

Cite This Study

Becker et al. (1973) studied this question.

synapsesocial.com/papers/6a0ff5a64fb650da4ffebd56 https://doi.org/10.1093/cvr/7.3.391

Topics

Coronary CT angiography

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Mapping of left ventricular blood flow with radioactive microspheres in experimental coronary artery occlusion

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Mapping of left ventricular blood flow with radioactive microspheres in experimental coronary artery occlusion

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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