Myocardial Blood Flow in Man: Effects of Coronary Collateral Circulation and Coronary Artery Bypass Surgery
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Why the study?
Does coronary artery bypass grafting improve myocardial blood flow in patients with coronary arterial obstructions?
Population
24 patients, mean age 48 years, undergoing coronary artery bypass procedure using saphenous vein grafts for…
Comparison
Coronary artery bypass graft open, allowing… vs Coronary artery bypass graft proximally…
Design
Cohort, The sequence of occlusion and patency of the graft was randomized.
Follow-up
Intraoperative
Authors
Discussion
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Implication
May augment MBF in severe stenoses; hypothesis-generating for outcomes in observational data.
Structured PICO
Does coronary artery bypass grafting improve myocardial blood flow in patients with coronary arterial obstructions?
P
Population
24 patients (21 male, 3 female), mean age 48 years (range 33-68), undergoing coronary artery bypass procedure using saphenous vein grafts for a total of 29 coronary arterial obstructions.
I
Intervention
Coronary artery bypass graft (CAB) open, allowing perfusion through the graft in addition to preexisting flow.
C
Comparator
Coronary artery bypass graft (CAB) proximally occluded, representing preexisting myocardial blood flow.
O
Outcome
Myocardial blood flow (MBF) measured intraoperatively by 133Xenon clearance.surrogate
Coronary artery bypass grafting significantly increases myocardial blood flow in vessels with >80% stenosis, whereas vessels with <80% stenosis have minimal resting flow impairment and minimal flow increase from bypass.
Cite This Study
Smith et al. (1972) studied this question.
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