What question did this study set out to answer?

The aim is to explore how cloned cytotoxic T lymphocytes recognize H-2 antigens, guided by the altered-self hypothesis.

Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis.

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Randomized trial shows cytotoxic T lymphocytes recognize specific H-2 antigens, indicating self-influence on T cell receptor development.

The aim is to explore how cloned cytotoxic T lymphocytes recognize H-2 antigens, guided by the altered-self hypothesis.
Radiation chimeras were created using H-2 heterozygous F1 stem cells and lethally irradiated parental hosts.
CTL clones were derived from selected populations and analyzed for target cell lysis.
Different H-2 strains and minor H backgrounds were tested for uniqueness in T cell recognition.
CTLs demonstrated lysis of both H-2d and H-2k target cells in an H-2 restricted manner.
H-2d restriction correlated with Dd mapping, while H-2k restriction corresponded with Kk mapping.
Recognition of various minor H antigens varied by H-2 restriction, confirming a link with T cell receptor specificity.

Hünig et al. (1982) studied this question.

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