Key result
Transcatheter aortic valve implantation significantly increased incremental shuttle walk distance from a median of 135 m to 185 m at 1 week post-procedure in patients with severe aortic stenosis.
Why the study?
To assess changes in peripheral skeletal muscle oxygenation during exercise after TAVI in patients with severe AS, and to identify characteristics of patients who showed improved exercise tolerance.
Does transcatheter aortic valve implantation improve peripheral skeletal muscle oxygenation and exercise tolerance in patients with severe symptomatic aortic stenosis?
Observational (n=20)
No
Does transcatheter aortic valve implantation improve peripheral skeletal muscle oxygenation and exercise tolerance in patients with severe symptomatic aortic stenosis?
TAVI improves early peripheral skeletal muscle oxygenation during exercise, and pre-TAVI oxygenation patterns can predict which patients will have improved exercise tolerance.
Early post-TAVI oxygenation gains may link to better exercise tolerance in severe AS; leaves open whether findings predict outcomes or warrant routine assessment.
Background: This study aimed to: (1) assess changes in peripheral skeletal muscle oxygenation during exercise after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis (AS); and (2) identify characteristics of patients who exhibited improved exercise tolerance. Methods and Results: In this single-center prospective study, 20 patients with severe symptomatic AS underwent evaluation before and 1 week after TAVI. Exercise tolerance was assessed using the incremental shuttle walk test (ISWT), and the incremental shuttle walk distance (ISWD) was recorded. Calf muscle oxygenation during the ISWT was continuously measured using near-infrared spectroscopy (NIRS). ISWD increased significantly after TAVI (P<0.01). During the ISWT, the change in oxygenated hemoglobin (∆O 2 Hb) was greater after TAVI than before TAVI. Compared with non-responders, responders demonstrated lower ∆O 2 Hb and greater increases in deoxygenated hemoglobin (∆HHb) from rest to peak exercise before TAVI (all P<0.05). Conclusions: Peripheral skeletal muscle oxygenation during exercise improved early after TAVI. Moreover, a pre-TAVI pattern characterized by reduced oxygen delivery (lower ∆O 2 Hb) and enhanced oxygen extraction/utilization (higher ∆HHb) during exercise was associated with greater improvement in exercise tolerance after TAVI.
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Tanaka et al. (2026) conducted an observational in Severe symptomatic aortic stenosis (n=20). Transcatheter aortic valve implantation (TAVI) vs. Pre-TAVI (baseline) was evaluated on Incremental shuttle walk distance (ISWD) (p=<0.01). Transcatheter aortic valve implantation significantly increased incremental shuttle walk distance from a median of 135 m to 185 m at 1 week post-procedure in patients with severe aortic stenosis.
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