Key result
Novel cardiopulmonary model successfully simulates the cardiovascular effects of mechanical ventilation and PEEP in ARDS.
Why the study?
Heart-lung interactions play a crucial role during mechanical ventilation, where positive pressure ventilation may harm cardiac pumping capacity, particularly in ARDS patients.
Can a mathematical cardiopulmonary model accurately simulate heart-lung interactions and the cardiovascular effects of mechanical ventilation in ARDS?
Can a mathematical cardiopulmonary model accurately simulate heart-lung interactions and the cardiovascular effects of mechanical ventilation in ARDS?
A newly developed mathematical cardiopulmonary model successfully simulates heart-lung interactions and the cardiovascular effects of mechanical ventilation, providing a tool for in silico testing.
May support in silico testing of ventilation effects in ARDS; leaves open prospective clinical validation before any practice consideration.
Heart-lung interactions plays a crucial role in mechanical ventilation, especially in acute respiratory distress syndrome (ARDS) patients. In general, positive pressure ventilation may harm the heart's pumping capacity. In this article a cardiopulmonary model is introduced, suitable e.g. for in silico testing. The aim is to simulate the heart-lung interactions and the influence of mechanical ventilation on the cardiovascular system. Therefore, a model of the respiratory system is extended by cardiovascular components and is evaluated using literature and clinical data. First, the pleura pressure is added to the thoracic compartments, and second, a shunt-blood pressure dependency is introduced for ARDS patients. In simulation, the relationship between heart rate to stroke volume, positive end-expiratory pressure (PEEP) to cardiac index, and the influence of pulmonary hypertension has been investigated. The simulations are in agreement with the comparator data. In summary, the results of the simulation of the newly developed model show that the model can simulate clinical data and, in particular, can reproduce the most significant effects of mechanical ventilation, especially PEEP.
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Hennigs et al. (2024) studied Acute respiratory distress syndrome (ARDS). Mathematical cardiopulmonary model vs. Literature and clinical data was evaluated on Simulation of heart-lung interactions and influence of mechanical ventilation on the cardiovascular system. A newly developed mathematical cardiopulmonary model successfully simulated clinical data to reproduce the significant cardiovascular effects of mechanical ventilation, particularly PEEP, in ARDS.
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