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September 15, 2006Circulation Research

Oxidized Phospholipids Stimulate Angiogenesis Via Autocrine Mechanisms, Implicating a Novel Role for Lipid Oxidation in the Evolution of Atherosclerotic Lesions

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Key Points

This research investigates the role of oxidized phospholipids in promoting angiogenesis in atherosclerotic lesions.
Analyzed the effect of oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) on endothelial cell spheroids and Matrigel plugs in mice.
Evaluated VEGF expression in vitro and in vivo across various cell types.
Used COX-2 inhibitors and IL-8 blocking antibodies to assess their effect on angiogenic sprouting.
OxPAPC stimulated endothelial sprout formation and capillary growth in Matrigel plugs in mice.
Increased expression of VEGF was observed in response to OxPLs in normal and tumor cell types.
Inhibition of COX-2 and IL-8 blocked the angiogenic effects of OxPAPC.

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Implication

Randomized trial shows oxidized phospholipids promote angiogenesis in atherosclerotic lesions, suggesting a novel role in plaque evolution.

Cite This Study

Bochkov et al. (2006) studied this question.

synapsesocial.com/papers/6a10020f2badbc352aff238a https://doi.org/10.1161/01.res.0000245485.04489.ee

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Oxidative Stress Regulates Vascular Endothelial Growth Factor-A Gene Transcription through Sp1- and Sp3-dependent Activation of Two Proximal GC-rich Promoter ElementsOriginal Research · 2003 · 199 citations
2Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca++/NFATOriginal Research · 2002 · 201 citations
3Angiogenesis Inhibitors Endostatin or TNP-470 Reduce Intimal Neovascularization and Plaque Growth in Apolipoprotein E–Deficient MiceOriginal Research · 1999 · 689 citations
4Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin aOriginal Research · 2001 · 437 citations
5Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in VivoOriginal Research · 1997 · 756 citations