Why the study?
Data were scarce on whether the pathophysiology and prognostic significance of inverted T waves in the ECG differ between different anatomical lead groups.
Does the anatomical location of T-wave inversion on ECG predict coronary heart disease and mortality in the general population?
Does the anatomical location of T-wave inversion on ECG predict coronary heart disease and mortality in the general population?
T-wave inversions in anterior and lateral leads are independently associated with CHD risk, and lateral inversions with mortality, whereas inferior T-wave inversions appear benign.
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T-wave inversion location may refine CHD risk assessment on ECG; extends observational data but remains hypothesis-generating.
Istolahti et al. (2020) studied this question.
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