What is the predictive value of established risk factors for total and cardiovascular disease mortality when measured before middle age? Pooled analyses of two prospective cohort studies from Scotland
Why the study?
Are established risk factors measured before middle age predictive of total and cardiovascular disease mortality up to four decades later?
Population
1503 individuals aged 16-35 years at baseline from two prospective cohort studies in Scotland
Design
Cohort
Follow-up
median 39.6 years
Authors
Discussion
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Member takes
Implication
Smoking and alcohol before middle age were associated with CVD mortality decades later; hypothesis-generating for early prevention timing.
Structured PICO
Are established risk factors measured before middle age predictive of total and cardiovascular disease mortality up to four decades later?
P
Population
1503 individuals aged 16-35 years at baseline from two prospective cohort studies in Scotland
I
Intervention
Physiological, behavioural and social characteristics (risk factors) measured before middle age
O
Outcome
Total and cardiovascular disease (CVD) mortality ascertained during 40 years of follow-uphard clinical
Cite This Study
Gray et al. (2010) studied this question.