Key result
Enterovirus positivity reaches ~60% in tested children as Coxsackievirus A6 becomes the predominant serotype.
Observational (n=9,676)
No
The study highlights a shift in enterovirus epidemiology in children, with CV-A6 replacing EV-A71 and CV-A16 as a predominant serotype, emphasizing the need for multivalent vaccines and multi-sample nucleic acid testing for viral encephalitis.
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May guide updated pediatric enterovirus surveillance; leaves open multivalent vaccine needs.
Lao et al. (2025) conducted an observational in Enterovirus infection (n=9,676). Between 2018 and 2023, 60.33% of 9676 tested children in Hangzhou were positive for enterovirus, with Coxsackievirus A6 becoming the predominant serotype as EV-A71 and CV-A16 rates declined.
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