Positive and negative affect and risk of coronary heart disease: Whitehall II prospective cohort study
Why the study?
Does positive or negative affect predict future coronary heart disease events in adults free of diagnosed coronary heart disease?
Population
10,308 civil servants aged 35-55 years at entry into Whitehall II study in 1985, free of diagnosed coronary…
Design
Cohort
Follow-up
mean 12.5 years
Authors
Discussion
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Member takes
Implication
Negative affect was associated with higher CHD incidence; hypothesis-generating and should not yet change practice or screening.
Structured PICO
Does positive or negative affect predict future coronary heart disease events in adults free of diagnosed coronary heart disease?
P
Population
10,308 civil servants aged 35-55 years at entry into Whitehall II study in 1985, free of diagnosed coronary heart disease at recruitment.
I
Intervention
Positive affect, negative affect, and affect balance score (highest third of negative affect)
O
Outcome
Composite of fatal coronary heart disease, clinically verified incident non-fatal myocardial infarction, and definite angina at mean follow-up 12.5 yearscomposite
Negative affect, but not positive affect, is weakly associated with an increased risk of future coronary heart disease events independent of established risk factors.
Cite This Study
Nabi et al. (2008) studied this question.