Why the study?
Does high continuity of statin treatment reduce all-cause mortality compared to low continuity in adult patients initiating statins for primary or secondary prevention?
Population
229,918 adult enrollees in a health maintenance organization in Israel who initiated statin treatment from…
Comparison
High continuity of statin treatment vs Low continuity of statin treatment (PDC <10%)
Design
Cohort
Follow-up
mean of 4.0 and 5.0 years for primary and secondary…
Authors
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Does not yet support changing practice; leaves open causal mortality benefit pending randomized evidence.
Does high continuity of statin treatment reduce all-cause mortality compared to low continuity in adult patients initiating statins for primary or secondary prevention?
High adherence to statin therapy (≥90% proportion of days covered) is associated with at least a 45% reduction in all-cause mortality in both primary and secondary prevention cohorts compared to poor adherence (<10%).
Shalev et al. (2009) studied this question.
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