Why the study?
Does sciatic nerve stimulation modulate the carotid sinus baroreceptor reflex in vagotomized cats?
Population
Anesthetized, immobilized, and vagotomized cats
Comparison
Sciatic nerve stimulation (SNS) vs Baseline (before sciatic nerve stimulation)
Design
Preclinical
Follow-up
20 seconds after onset of stimulation
Authors
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Attenuates baroreflex sensitivity in vagotomized cats; leaves open translation to intact models or clinical neuromodulation.
Does sciatic nerve stimulation modulate the carotid sinus baroreceptor reflex in vagotomized cats?
Sciatic nerve stimulation attenuates the sensitivity of arterial pressure and heart rate responses in the carotid sinus baroreceptor reflex in vagotomized cats, primarily through modulation of cardiac output.
Kumada et al. (1975) studied this question.
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