What question did this study set out to answer?

To compare the acute effects of adaptive servo-ventilation against nasal oxygen, CPAP, and bilevel positive airway pressure on sleep quality and disordered breathing in patients with heart failure and Cheyne-Stokes respiration.

August 1, 2001American Journal of Respiratory and Critical Care Medicine

Adaptive Pressure Support Servo-Ventilation

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To compare the acute effects of adaptive servo-ventilation against nasal oxygen, CPAP, and bilevel positive airway pressure on sleep quality and disordered breathing in patients with heart failure and Cheyne-Stokes respiration.
Fourteen subjects (N=14) with stable cardiac failure on optimal medical therapy underwent polysomnography under five conditions: untreated baseline and four treatment nights in random order (nasal oxygen at 2 L/min, CPAP mean 9.25 cm H2O, bilevel mean 13.5/5.2 cm H2O, and ASV mean 7–9 cm H2O).
ASV significantly decreased the thermistor apnea-hypopnea index (AHI) from 44.5 ± 3.4/h untreated to 6.3 ± 0.9/h, outperforming oxygen (28.2 ± 3.4/h), CPAP (26.8 ± 4.6/h, both p < 0.001 vs. control), and bilevel support (14.8 ± 2.3/h, p < 0.001 vs. ASV).
Arousal index dropped from 65.1 ± 3.9/h untreated to 14.7 ± 1.8/h on ASV (p < 0.01 vs. all treatments except bilevel at 16.0 ± 1.3/h), accompanied by notable increases in slow-wave and REM sleep that did not occur with oxygen or CPAP.
All 14 subjects preferred ASV over standard CPAP therapy.

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Implication

Randomized trial demonstrates superior reduction of central sleep apnea and improved sleep architecture with adaptive servo-ventilation in heart failure, indicating high clinical efficacy.

Cite This Study

Teschler et al. (2001) studied this question.

synapsesocial.com/papers/6a1013ddd13714ec96ff1f7c https://doi.org/10.1164/ajrccm.164.4.9908114

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Implication

Randomized trial demonstrates superior reduction of central sleep apnea and improved sleep architecture with adaptive servo-ventilation in heart failure, indicating high clinical efficacy.

Adaptive Pressure Support Servo-Ventilation

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Adaptive Pressure Support Servo-Ventilation

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Implication

Cite This Study

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