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February 1, 1975The Journal of Pathology

Experimental bacterial endocarditis. IV. Structure and evolution of very early lesions

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Authors

DDDavid T. DurackCross-Cutting Cardiology

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Implication

Experimental analysis reveals the structure of early lesions in endocarditis, suggesting phagocytosis initiates growth.

Key Points

  • This research aims to examine the early lesions in bacterial endocarditis and understand their structure and evolution.
  • Studied lesions using light, immunofluorescent, and electron microscopy.
  • Injected Thorotrast intravenously to examine accumulations of phagocytes.
  • Analyzed bacterial adhesion on early vegetations after intravenous injection of streptococci.
  • Early lesions feature platelet masses and fibrin strands, indicating a complex structure.
  • Mononuclear phagocytes accumulated at sterile vegetations after Thorotrast injection, showing significant phagocytosis.
  • Bacterial colonies formed rapidly, achieving protective layers of fibrin against phagocytosis.

Cite This Study

David T. Durack (1975) studied this question.

synapsesocial.com/papers/6a10197ed13714ec96ff29b2https://doi.org/10.1002/path.1711150204
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A New Method for the Production of Experimental Bacterial Endocarditis1950 · 25 citations
  2. 2CHEMOTAXIS OF MONONUCLEAR CELLS1968 · 210 citations
  3. 3MECHANISMS OF ACQUIRED RESISTANCE IN MOUSE TYPHOID1966 · 286 citations