Why the study?
Nemaline myopathy lacks curative treatments, and whether knocking out MuRF1 could ameliorate muscle deficits in nemaline myopathy with muscle atrophy was unknown.
Does knocking out MuRF1 improve muscle mass and function in mouse models of Nemaline myopathy?
Population
Two NEM2 mouse models of nemaline myopathy (typical and severe forms)
Comparison
MuRF1 KO cross vs NEM2 disease models
Design
Preclinical animal study
Authors
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Increased muscle mass without force gains in NM models cautions against MuRF1 targeting; leaves open functional benefits in other models.
Does knocking out MuRF1 improve muscle mass and function in mouse models of Nemaline myopathy?
Knocking out MuRF1 in Nemaline myopathy mouse models increases muscle mass but fails to provide functional benefits in force production.
Lindqvist et al. (2022) studied this question.
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