October 17, 2018PLoS ONEOpen Access

Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy

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Population

induced Pluripotent Stem Cell-derived cardiomyocytes generated from skin fibroblasts of patients with…

Design

Preclinical

Authors

RSRevital SchickKlinikum rechts der Isar LMLucy N. MekiesTechnion – Israel Institute of Technology YSYuval ShemerTechnion – Israel Institute of Technology

Discussion

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Implication

iPSC-CM models warrant further DCM research but should not change practice; leaves open in vivo validation and therapeutic translation.

Structured PICO

Population

induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CM) generated from skin fibroblasts of patients with titin (TTN)-mutated dilated cardiomyopathy (DCM)

Intervention

In vitro functional and structural assays including exposure to isoproterenol, increased extracellular calcium, angiotensin-II, and caffeine

Outcome

Sarcomeric organization, inotropic and lusitropic responses, and proteome profilesurrogate

iPSC-derived cardiomyocytes from patients with titin-mutated dilated cardiomyopathy successfully recapitulate the disease phenotype in vitro, demonstrating defective sarcomeric organization and blunted inotropic responses.

Cite This Study

Schick et al. (2018) studied this question.

synapsesocial.com/papers/6a101a86d8c5cf602efdaa3d https://doi.org/10.1371/journal.pone.0205719

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Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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