Key result
The interaction between the NH2-terminal titin Ig repeats Z1 and Z2 and a novel 19-kD protein (titin-cap) is required for the structural integrity of sarcomeres in cardiac myocytes.
The interaction between the NH2-terminal titin Z1-Z2 domains and the novel protein titin-cap is critical for sarcomeric assembly and structural integrity in cardiac myocytes.
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Should not yet change practice; leaves open titin-cap targeting in human cardiomyopathy.
Gregorio et al. (1998) studied Sarcomeric integrity. Dominant-negative titin Z1-Z2 domains and titin-cap was evaluated on Structural integrity of sarcomeres. The interaction between the NH2-terminal titin Ig repeats Z1 and Z2 and a novel 19-kD protein (titin-cap) is required for the structural integrity of sarcomeres in cardiac myocytes.
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