Key result
Resting parasympathetic activity inversely correlates with systolic BP, resting HR, and max carotid flow in adolescents.
Why the study?
Is parasympathetic activity related to cardiovascular and metabolic risk markers in healthy pre-pubertal adolescents?
Cross-Sectional (n=99)
Is parasympathetic activity related to cardiovascular and metabolic risk markers in healthy pre-pubertal adolescents?
Effect estimate: β=-0.319 (95% CI -0.638; -0.001)
Parasympathetic activity at rest is inversely related to cardiovascular risk markers such as systolic blood pressure and blood flow in healthy pre-pubertal adolescents, suggesting heart rate variability could help identify those at increased risk.
May support HRV for adolescent risk stratification; leaves open causal links and need for prospective validation.
OBJECTIVE: To analyse the relationship between different heart rate variability indices, resting heart rate, and cardiovascular markers in adolescents. METHODS: A cross-sectional study was carried out with information from an ongoing cohort study. The sample was composed of 99 adolescents who complied with the following inclusion criteria: aged between 11 and 14 years; enrolled in a school unit of elementary education; absence of any known diseases; no drug consumption; and a formal consent signed by the parents or legal guardians. Weight, height, heart rate variability, lipid profile, inflammatory markers, blood pressure, resting heart rate, intima-media thickness, blood flow, and trunk fatness were measured. Partial correlation and linear regression (expressed by β and 95% confidence intervals [95%CI]) analyses were used to analyse the relationships between the variables. RESULTS: In the linear regression analysis, even after adjustments for sex, age, trunk fatness, and somatic maturation, parasympathetic activity presented significant correlations with maximum carotid artery blood flow (β=-0.111 [95%CI=-0.216; -0.007]), systolic blood pressure (β=-0.319 [95%CI=-0.638; -0.001]), and resting heat rate (β=-0.005 [95%CI=-0.009; -0.002]). CONCLUSION: Parasympathetic activity at rest is inversely related to maximum and minimum blood flow, triacylglycerol levels, and systolic blood pressure. These findings suggest that heart rate variability has the potential to discriminate pre-pubertal adolescents at increased risk.
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Cayres et al. (2015) conducted a cross-sectional in Healthy adolescents (n=99). Parasympathetic activity (Heart rate variability) was evaluated on Correlation between parasympathetic activity and cardiovascular markers (e.g., systolic blood pressure) (β=-0.319, 95% CI -0.638; -0.001). Parasympathetic activity at rest was inversely correlated with systolic blood pressure (β=-0.319; 95% CI -0.638 to -0.001), maximum carotid blood flow, and resting heart rate in adolescents.
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