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May 5, 2003Circulation

Participants in the uppermost (>72.7 bpm) versus the lowest (<=60.1 bpm) quartile of HR had a 60% increased risk (95% CI 33%-92%) of developing diabetes.

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Why the study?

Does autonomic nervous system dysfunction increase the risk of developing type 2 diabetes in healthy adults?

Population

8,185 men and women aged 45 to 64 years from the Atherosclerosis Risk In Communities study

Comparison

Autonomic nervous system dysfunction, estimated… vs Normal autonomic nervous system function

Design

Cohort

Follow-up

mean 8.3 years

Authors

MCMercedes R. CarnethonSGSherita Hill GoldenAFAaron R. Folsom

Discussion

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Member takes

Overview

High resting HR may flag diabetes risk in healthy adults; leaves open whether autonomic dysfunction is causal.

Structured PICO

Does autonomic nervous system dysfunction increase the risk of developing type 2 diabetes in healthy adults?

P
Population
8,185 men and women aged 45 to 64 years from the Atherosclerosis Risk In Communities study
I
Intervention
Autonomic nervous system dysfunction, estimated by high heart rate (highest quartile, >72.7 bpm) and low heart rate variability (lowest quartile, <7.7 ms2)
C
Comparator
Normal autonomic nervous system function (lowest quartile of heart rate, <=60.1 bpm, and highest quartile of heart rate variability, >=38.9 ms2)
O
Outcome
Incident type 2 diabetes

Autonomic nervous system dysfunction, indicated by high heart rate and low heart rate variability, is associated with an increased risk of developing type 2 diabetes in healthy adults.

Cite This Study

Carnethon et al. (2003) studied this question.

synapsesocial.com/papers/6a101b2e8090e499da60a260https://doi.org/10.1161/01.cir.0000066324.74807.95
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