Assessment of oxidative balance score with hypertension and arterial stiffness in children and adolescents: NHANES 2001–2018

OBJECTIVE: To investigate the complex relationship between oxidative balance score (OBS), hypertension (HTN) and arterial stiffness in children and adolescents utilizing data gathered from the National Health and Nutrition Examination Survey (NHANES). STUDY DESIGN: Through utilizing NHANES data (2001-2018), OBS, comprising dietary and lifestyle components, was calculated and categorized into tertiles. The correlation between OBS and HTN was explored employing weighted multivariate logistic regression. Stratified analyses were further performed to evaluate the associations across different subgroups. RESULTS: A total of 11,754 children and adolescents were ultimately enrolled in analyses. High OBS tertiles demonstrated a consistent negative association with HTN across models. Compared with the lowest OBS tertile, the risk of HTN in the highest OBS tertile was decreased by 37% (95% CI 0.44-0.90, p = 0.011). After dividing OBS into dietary OBS and lifestyle OBS, Lifestyle OBS exhibited a significant inverse association with HTN, while dietary OBS showed no significant correlation. Stratified analyses notably revealed the protective impacts of OBS on the risk of HTN in males. Restricted cubic spline analysis confirmed a nonlinear association between OBS and HTN. Moreover, the elevated OBS was significantly associated with decreased ePWV, indicating a potential link between arterial stiffness and OBS. CONCLUSION: In summary, the risk of HTN was inversely correlated with high OBS. Adopting a wholesome lifestyle enriched with antioxidants to boost OBS may help shield children from HTN risk.