Why the study?
The mechanisms underlying ischemia-reperfusion injury after reperfusion treatment for myocardial infarction are incompletely understood and effective pharmacological interventions are limited.
Does disulfiram reduce cardiomyocyte death and improve heart function after ischemic injury in preclinical models?
Population
Cardiomyocytes and rats with myocardial ischemia-reperfusion injury
Comparison
Disulfiram vs comparator
Design
Preclinical high-throughput chemical screening and animal study
Authors
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Hypothesis-generating for disulfiram in ischemia-reperfusion injury; prospective human trials needed before clinical consideration.
Does disulfiram reduce cardiomyocyte death and improve heart function after ischemic injury in preclinical models?
Disulfiram shows potential as a cardioprotective agent against ischemia-reperfusion injury by inhibiting Gasdermin D.
Chen et al. (2023) studied this question.
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