Does amplified negative affective responsivity to daily stressors increase urinary norepinephrine excretion in middle-aged adults?
Emotional vulnerability to daily stressors is associated with sympathetic overactivation, providing a potential mechanistic link to future cardiovascular risk.
Few studies have examined sympathetic dysregulation as a potential mechanism linking affective responsivity to daily stressors to future cardiovascular diseases. Using a large national sample, our findings show that amplified negative affective responsivity to daily stressors is related to increased urinary norepinephrine excretion independent of the frequency of stressor occurrence. These data suggest that chronic sympathetic overactivation may contribute to the link between emotional vulnerability to daily stressors and increased risk of future cardiovascular comorbidities.
Gloger et al. (2025) studied this question.