Greater Daily Psychosocial Stress Exposure is Associated With Increased Norepinephrine‐Induced Vasoconstriction in Young Adults
Key result
Greater daily psychosocial stress exposure was significantly associated with increased maximal norepinephrine-induced vasoconstriction (R2=0.40; P<0.01).
Why the study?
Epidemiological data link psychological stress with increased cardiovascular disease risk, but the underlying mechanisms remain incompletely understood.
Does daily psychosocial stress exposure increase norepinephrine-induced vasoconstriction in healthy adults?
Comparison
Varying frequency and total exposure to daily psychosocial stressors
Design
Observational cohort study
Follow-up
8 consecutive evenings
Authors
Discussion
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Member takes
Implication
Psychosocial stress may heighten vascular reactivity; hypothesis-generating and should not yet change practice.
Study Design
Type
Observational (n=18)
Structured PICO
Does daily psychosocial stress exposure increase norepinephrine-induced vasoconstriction in healthy adults?
P
Population
18 healthy adults aged 19-36 years assessed for daily psychosocial stress exposure over 8 consecutive days.
E
Exposure
Daily psychosocial stress exposure (assessed via daily telephone interviews for 8 consecutive evenings)
O
Outcome
Microvascular adrenergic vasoconstrictor responsiveness (measured by red cell flux during graded intradermal microdialysis perfusion of norepinephrine)surrogate
Main Result
Effect estimate: R2=0.40
p-value: p=<0.01
Daily psychosocial stress exposure is associated with increased microvascular vasoconstrictor responsiveness to norepinephrine in healthy young adults, suggesting a mechanism for stress-related cardiovascular risk.
Cite This Study
Greaney et al. (2020) conducted an observational in Healthy adults (n=18). Daily psychosocial stress exposure was evaluated on Norepinephrine-induced vasoconstriction (R2=0.40, p=<0.01). Greater daily psychosocial stress exposure was significantly associated with increased maximal norepinephrine-induced vasoconstriction (R2=0.40; P<0.01).