February 17, 2018Journal of the American Heart AssociationOpen Access

Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium‐Derived Endothelin‐1

View Full Paper

Ask AI

Bookmark

Why the study?

Does endothelium-derived ET-1 contribute to the acute pressor response to psychosocial stress in mice?

Population

Adult male vascular endothelium-specific ET-1 knockout mice and control mice homozygous for the floxed allele

Comparison

Acute psychosocial stress with or without 3-day… vs Control mice homozygous for the floxed allele…

Design

Preclinical

Discussion

Member takes

Implication

Hypothesis-generating for endothelial ET-1 in stress hypertension; leaves open translation to human therapy.

Structured PICO

Does endothelium-derived ET-1 contribute to the acute pressor response to psychosocial stress in mice?

Population

Adult male vascular endothelium-specific ET-1 knockout mice and control mice homozygous for the floxed allele

Intervention

Acute psychosocial stress (cage switch stress, CSS) with or without 3-day pretreatment with endothelin A antagonist (ABT-627) or dual endothelin A/B receptor antagonist (A-182086)

Comparator

Control mice homozygous for the floxed allele exposed to the same stress

Outcome

Acute pressor response (blood pressure) measured by telemetrysurrogate

Endothelium-derived ET-1 and subsequent endothelin A receptor activation are novel mediators of the blood pressure response to acute psychosocial stress.

Cite This Study

A 2018 study studied this question.

synapsesocial.com/papers/6a815c1bd7cc367643662948 https://doi.org/10.1161/jaha.117.007863

View Full Paper

Ask AI

Bookmark