Key result
African American and male adolescents exhibited higher ET-1 and blood pressure at rest and greater increases during acute stress compared to European Americans and females.
Why the study?
Do ethnicity and sex influence plasma ET-1 levels and hemodynamic reactivity in response to acute stress in adolescents?
Observational (n=222)
Do ethnicity and sex influence plasma ET-1 levels and hemodynamic reactivity in response to acute stress in adolescents?
Answers are grounded in this paper and cite their sources.
African American and male adolescents exhibit higher baseline and stress-induced levels of ET-1 and blood pressure, suggesting a potential mechanism for demographic differences in cardiovascular disease prevalence.
Objectives The purposes of this study were to examine possible ethnic and sex differences in plasma ET-1 levels at rest and in response to acute stress and to examine relationships between ET-1 and vasoconstrictive-mediated BP reactivity to stress. Methods Two hundred twenty-two adolescents (mean age = 18.5 ± 2.8 years; 130 [70 males] EAs and 92 [48 males] AAs) completed two stressors (video game, forehead cold). Hemodynamic measures and blood samples were collected at catheter insertion and before and immediately after the two stressors, separated by 20-minute rest periods. Results AAs and males exhibited higher levels of SBP and DBP and of TPRI and ET-1 at each sampling point compared with EAs and females, respectively (p values < .001). AAs and males exhibited greater increases in SBP, TPRI, and ET-1 in response to each stressor (p values < .05). Intraindividual correlations between ET-1 and hemodynamic parameters revealed that most individuals exhibited a positive association between ET-1, BP, and TPRI. However, some individuals exhibited a negative association between ET-1 and the above-mentioned hemodynamics, suggesting a compensatory vasodilation mechanism. Conclusion The findings demonstrate significant sex and ethnicity differences in stress-induced vasoconstrictive peptide release and support the hypothesis that these differences may be important in explaining the ethnicity and sex differences in the prevalence of cardiovascular disease.
No takes yet. Share an insight, caveat, or question.
Treiber et al. (2002) reported an observational. Acute stress, African American ethnicity, and male sex vs. Rest, European American ethnicity, and female sex was evaluated on Plasma ET-1 levels and hemodynamic measures (SBP, DBP, TPRI) at rest and in response to acute stress (p=<0.001). African American and male adolescents exhibited higher ET-1 and blood pressure at rest and greater increases during acute stress compared to European Americans and females.
Synapse has enriched 10 related papers. Consider them for comparative context: