Role of Serotonin, Membrane Transporter, and 5-HT2 Receptors in Pathogenesis of Atherosclerotic Plaque Formation in Immature Heterozygous Low-Density Lipoprotein-Receptor-Deficient Mice

Figures

• 

  Figure 1. Normal histological structure of the aorta in mice: 1—inner sheath, 2—middle sheath, and 3—adventitial sheath. Control group. Haematoxylin and eosin staining. ×400.

• 

  Figure 2. mAb expression against SERT in the mouse aorta (1). Control group. LSAB method with hematoxylin staining. ×400.

• 

  Figure 3. mAb expression against SERT. Control group. LSAB method with hematoxylin staining. ×400: expression (a) in the endothelium in mouse myocardial vessels (1); (b) in mouse cardiomyocytes (1).

• 

  Figure 4. Deposition of eosinophilic hyaline-like masses (1) in the aortic intima of mice. 2—vessel lumen; 3—adventitial sheath. Main group. Haematoxylin and eosin staining. ×200.

• 

  Figure 5. Lipid accumulation in the form of focal infiltration with the onset of atherosclerotic plaque formation (1) bulging into the lumen (2) of the aorta in mice. Main group. Haematoxylin and eosin. ×200.

• 

  Figure 6. Mouse aorta. Main group: (a) Xanthoma cells (1); lipids (2). ×400. (b) Lipids in the aortic intima of mice. Sudan III staining. ×400.

• 

  Figure 7. mAb expression against 5HT2A and 5HT2B. Main group. Mouse aorta. LSAB method with hematoxylin staining. ×400: (a) mAb expression against 5HT2A; (b) mAb expression against 5HT2B.

• 

  Figure 8. Expressed reaction of mAbs vs. SERT (1) in the area of hyaline-like mass deposition (2). Main group. LSAB method with haematoxylin staining. ×200.

• 

  Figure 9. Lipids (1) in the myocardial stroma of mice. Main group. Sudan III staining. ×400.

• 

  Figure 10. mAb expression against 5HT2A and 5HT2B. Main group. Myocardium. LSAB method with hematoxylin staining. ×400: (a) mAb expression against 5HT2A; (b) mAb expression against 5HT2B.