What question did this study set out to answer?

To update evidence-based clinical recommendations from the British Society for Haematology on the diagnosis and prognostic assessment of primary, post-essential thrombocythaemia, post-polycythaemia vera, and prefibrotic myelofibrosis.

November 6, 2023British Journal of HaematologyOpen Access

Diagnosis and evaluation of prognosis of myelofibrosis: A British Society for Haematology Guideline

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Authors

DMDonal P. McLornan AGAnna L. Godfrey AGAnna Green

Discussion

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Overview

Clinical guideline outlines diagnostic and prognostic frameworks in myelofibrosis, highlighting molecular stratification and integrated pathology.

Key Points

To update evidence-based clinical recommendations from the British Society for Haematology on the diagnosis and prognostic assessment of primary, post-essential thrombocythaemia, post-polycythaemia vera, and prefibrotic myelofibrosis.
Literature searches were conducted across Medline, PubMed, and Cochrane covering human clinical studies, trials, and meta-analyses published from 2012 to mid-2022.
Evidence quality and recommendation strength were appraised using GRADE criteria, with review by the BSH Guidelines Committee, patient representatives, and external international experts.
Bone marrow evaluation requiring reticulin grading (minimum grade 2) alongside screening for driver mutations (JAK2, CALR, MPL) forms the core diagnostic requirement to differentiate myelofibrosis from mimics.
Comprehensive myeloid next-generation sequencing panels covering high molecular risk genes (e.g., ASXL1, SRSF2, EZH2, IDH1/2) and cytogenetic testing are recommended to refine risk in transplant-eligible and high-risk cohorts.
Prognostic models—including IPSS, DIPSS-plus, MIPSS70+ v2.0, MYSEC-PM, and personalised calculators—must be dynamically applied at regular intervals to guide therapy and transplant planning.

Cite This Study

McLornan et al. (2023) studied this question.

synapsesocial.com/papers/6a1027ea5725bbd5cc609639 https://doi.org/10.1111/bjh.19164

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November 6, 2023British Journal of HaematologyOpen Access

Diagnosis and evaluation of prognosis of myelofibrosis: A British Society for Haematology Guideline

View Full Paper

Ask AI

Bookmark

Authors

DMDonal P. McLornan AGAnna L. Godfrey AGAnna Green

Discussion

Member takes

Overview

Clinical guideline outlines diagnostic and prognostic frameworks in myelofibrosis, highlighting molecular stratification and integrated pathology.

Key Points

To update evidence-based clinical recommendations from the British Society for Haematology on the diagnosis and prognostic assessment of primary, post-essential thrombocythaemia, post-polycythaemia vera, and prefibrotic myelofibrosis.
Literature searches were conducted across Medline, PubMed, and Cochrane covering human clinical studies, trials, and meta-analyses published from 2012 to mid-2022.
Evidence quality and recommendation strength were appraised using GRADE criteria, with review by the BSH Guidelines Committee, patient representatives, and external international experts.
Bone marrow evaluation requiring reticulin grading (minimum grade 2) alongside screening for driver mutations (JAK2, CALR, MPL) forms the core diagnostic requirement to differentiate myelofibrosis from mimics.
Comprehensive myeloid next-generation sequencing panels covering high molecular risk genes (e.g., ASXL1, SRSF2, EZH2, IDH1/2) and cytogenetic testing are recommended to refine risk in transplant-eligible and high-risk cohorts.
Prognostic models—including IPSS, DIPSS-plus, MIPSS70+ v2.0, MYSEC-PM, and personalised calculators—must be dynamically applied at regular intervals to guide therapy and transplant planning.

Cite This Study

McLornan et al. (2023) studied this question.

synapsesocial.com/papers/6a1027ea5725bbd5cc609639 https://doi.org/10.1111/bjh.19164

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