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June 23, 2026International Journal of Cancer

Primary Myelofibrosis ( PMF )—The German ONKOPEDIA Guideline 2025

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Authors

MGMartin GrießhammerJohannes Wesling Klinikum MindenHAHaifa Kathrin Al‐AliUniversity Hospital in HalleGBGabriela M. BaerlocherKlinik Hirslanden

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Implication

Guideline updates on diagnosing and treating myelofibrosis in patients with varying risk levels, suggesting new therapeutic strategies.

Key Points

  • This guideline aims to provide comprehensive updates on the diagnosis and treatment of primary myelofibrosis.
  • Reviewed recent WHO and ICC diagnostic criteria updates published in 2022.
  • Summarized treatment options, including JAK inhibitors and stem cell transplantation.
  • Outlined patient prognosis factors and the role of cytogenetic/molecular markers.
  • Identified pre-PMF and classic PMF based on diagnostic characteristics.
  • Ruxolitinib is established as first-line treatment, with fedratinib and momelotinib offering additional options.
  • Emphasized the need for individualized treatment based on genetic factors and symptom severity.

Cite This Study

Grießhammer et al. (2026) studied this question.

synapsesocial.com/papers/6a3a223b111626ef22ab6dc0https://doi.org/10.1002/ijc.70596
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Path Forward in MF: Small Molecules in the Limelight2026
  2. 2Distinct clinical, molecular, and treatment response profiles in primary and secondary myelofibrosis: a single-center retrospective study2026
  3. 3Primary Myelofibrosis: Update on Definition, Pathogenesis, and Treatment2008 · 95 citations
  4. 4Myelofibrosis: Current unmet needs, emerging treatments, and future perspectives2024 · 11 citations
  5. 5Myelofibrosis management in routine clinical practice with a focus on patients with cytopenias: recommendations from a global consensus group2024 · 5 citations