January 1, 1990Cell Motility and the Cytoskeleton

Ultrastructural cytoskeleton alterations and modification of actin expression in the NIH/3T3 cell line after transformation with Ha‐ras‐Activated oncogene

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Population

NIH/3T3 fibroblast monolayers

Design

Preclinical

Authors

LLLuciano LombardiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico DBDario BallinariNerviano Medical Sciences IBItalia BongarzoneFondazione IRCCS Istituto Nazionale dei Tumori

Discussion

Member takes

Implication

These cytoskeletal changes in ras-transformed fibroblasts should not yet inform oncology practice; leaves open their mechanistic role in human transformation.

Structured PICO

Population

NIH/3T3 fibroblast monolayers

Intervention

Transfection with Ha-ras-activated oncogene

Outcome

Cytoskeleton alterations and modification of actin expressionsurrogate

Ha-ras oncogene transformation in NIH/3T3 fibroblasts leads to significant cytoskeletal alterations including loss of stress fibers and down-regulation of alpha-actin.

Cite This Study

Lombardi et al. (1990) studied this question.

synapsesocial.com/papers/6a1027ef92676d5461fda20f https://doi.org/10.1002/cm.970150405

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Implication

These cytoskeletal changes in ras-transformed fibroblasts should not yet inform oncology practice; leaves open their mechanistic role in human transformation.

Ultrastructural cytoskeleton alterations and modification of actin expression in the NIH/3T3 cell line after transformation with Ha‐ras‐Activated oncogene

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ultrastructural cytoskeleton alterations and modification of actin expression in the NIH/3T3 cell line after transformation with Ha‐ras‐Activated oncogene

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider