Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.
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Discussion
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Implication
Investigation reveals fibronectin receptor signaling impacts gene expression for collagen-degrading enzymes, indicating its role in matrix regulation.
Key Points
- This research aims to understand how ligation of the fibronectin receptor affects gene expression in fibroblasts.
- Investigated gene expression changes in rabbit synovial fibroblasts after treatment with anti-fibronectin receptor antibodies.
- Utilized monoclonal antibodies to assess receptor interactions and gene induction.
- Examined effects of cross-linking fibronectin-derived fragments on metalloproteinase gene expression.
- Treatment with anti-fibronectin receptor antibodies induced mRNA accumulation for collagenase and stromelysin.
- Gene expression was not influenced by other membrane glycoprotein receptors or native fibronectin adhesion.
- Cross-linking of the anti-fibronectin receptor enhanced gene induction, suggesting a complex signaling mechanism.
Cite This Study
Werb et al. (1989) studied this question.