Why the study?
How does cardiovascular aging affect carotid flow waveforms and derived indexes in an in silico virtual population?
How does cardiovascular aging affect carotid flow waveforms and derived indexes in an in silico virtual population?
In silico modeling demonstrates that carotid flow augmentation index is a strong indicator of local carotid stiffness, highlighting the potential of carotid ultrasound waveforms for assessing cardiovascular aging.
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Hypothesis-generating for noninvasive carotid assessment of aging; leaves open human validation before any clinical use.
An age-specific virtual population was generated based on a 1-D model of the arterial circulation, including newly defined literature-based specific age variations in carotid vessel properties. Simulated carotid flow/velocity waveforms, indexes, and age trends were statistically validated against in vivo data from the literature. A comprehensive study of the impact of aging on carotid flow waveform morphology was performed, and the mechanisms influencing different carotid indexes were elucidated. Notably, flow augmentation index (FAI) was found to be a strong indicator of local carotid stiffness.
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Suriani et al. (2024) studied this question.
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