January 1, 1992
Alterations of the force-frequency relationship in the failing human heart depend on the underlying cardiac disease
Population
Non-failing human myocardium and end-stage failing human myocardium due to dilated cardiomyopathy or…
Comparison
Increasing stimulation frequency and increasing… vs Non-failing myocardium and baseline Ca2+…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Etiology-specific force-frequency changes in animal myocardium leave open calcium modulation strategies in human dilated cardiomyopathy; requires prospective validation.
Structured PICO
P
Population
Non-failing human myocardium and end-stage failing human myocardium due to dilated cardiomyopathy or subacute myocarditis
I
Intervention
Increasing stimulation frequency (0.5-3 Hz) and increasing extracellular Ca(2+)-concentration (from 2.5 to 7.2 mM)
C
Comparator
Non-failing myocardium (control) and baseline Ca2+ concentration (2.5 mM)
O
Outcome
Force of contractionsurrogate
Alterations in the force-frequency relationship in failing human myocardium depend on the specific underlying etiology (dilated cardiomyopathy vs subacute myocarditis) and are aggravated by increased extracellular calcium.
Cite This Study
Pieske et al. (1992) studied this question.