Why the study?
How does atrial pressure correlate with ventricular stroke work in a complete circulation model?
How does atrial pressure correlate with ventricular stroke work in a complete circulation model?
This foundational study demonstrates a consistent correlation between atrial pressure and ventricular stroke work, introducing the concept of a family of ventricular function curves that expands upon Starling's law.
Challenges classical descending limb in normal hearts; leaves open human translation and disease-state validation.
Starling's law of the heart has been studied in the dog with a complete circulation with the continuous registration of cardiac output, and atrial and arterial pressures. From this data ventricular function curves were constructed. In any given physiologic state there was a consistent and reproducible correlation between atrial pressure and ventricular stroke work on the same side. The classically conceived descending limb did not occur in the normal heart. The concept of a family of Starling or ventricular function curves adds a third dimension to the adaptive capacity of the heart as put forth by Frank and Starling.
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Sarnoff et al. (1954) studied this question.
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