Why the study?
Are forward and backward traveling pressure waves associated with subclinical carotid artery wall remodeling and central pulse pressure in healthy adults?
Are forward and backward traveling pressure waves associated with subclinical carotid artery wall remodeling and central pulse pressure in healthy adults?
The backward pressure wave is directly associated with subclinical carotid artery remodeling (cIMT), whereas the forward pressure wave is associated with greater central pulse pressure, highlighting distinct pathophysiological roles of pulsatile hemodynamic components.
Supports distinct wave roles in remodeling vs PP; hypothesis-generating and should not yet change practice.
The present study contributes to the growing body of evidence highlighting the physiological and clinical insight provided by the pulsatile hemodynamic components of central artery pulse pressure. The notable findings of this study are: 1) The reflected (backward) pressure wave is associated with carotid intima-media thickness independent of traditional cardiovascular risk factors, including systolic blood pressure and aortic stiffness. 2) The incident (forward) pressure wave, and not the reflected pressure wave, is associated with greater central pulse pressure.
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Armstrong et al. (2023) studied this question.
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