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September 28, 1999Circulation

Association Between Local Pulse Pressure, Mean Blood Pressure, and Large-Artery Remodeling

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Why the study?

Does local pulse pressure or mean blood pressure influence arterial remodeling in elastic versus muscular arteries?

Population

167 humans, comprising 43 healthy subjects and 124 never-treated hypertensive patients

Design

Cross-sectional

Authors

PBPierre BoutouyrieVascular MedicineCBCaroline BussySorbonne UniversitéPLPatrick LacolleyVascular Medicine

Discussion

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Implication

Hypothesis-generating for artery-specific BP effects on remodeling; leaves open whether local pulse pressure targets alter outcomes.

Structured PICO

Does local pulse pressure or mean blood pressure influence arterial remodeling in elastic versus muscular arteries?

P
Population
167 humans, comprising 43 healthy subjects and 124 never-treated hypertensive patients
O
Outcome
Intima-media thickness and internal diameter of the carotid and radial arteriessurrogate

Local pulse pressure is a strong independent determinant of arterial remodeling in elastic arteries like the carotid, whereas mean blood pressure influences remodeling in muscular arteries like the radial artery.

Cite This Study

Boutouyrie et al. (1999) studied this question.

synapsesocial.com/papers/6a7cf9521e80ecf5247bf9aehttps://doi.org/10.1161/01.cir.100.13.1387

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ultrasound evaluation of atherosclerotic manifestations in the carotid artery in high-risk hypertensive patients. Risk Intervention Study (RIS) Group.1994 · 96 citations
  2. 2Systolic Blood Pressure, Arterial Rigidity, and Risk of Stroke1981 · 352 citations
  3. 3Systolic blood pressure, arterial rigidity, and risk of stroke. The Framingham study1981 · 492 citations
  4. 4Mechanical Strain Increases Smooth Muscle and Decreases Nonmuscle Myosin Expression in Rat Vascular Smooth Muscle Cells1996 · 232 citations
  5. 5Relation of pulse pressure and blood pressure reduction to the incidence of myocardial infarction.1994 · 609 citations