Why the study?
Does increased pulsatile pressure and flow alter arterial wall morphology and composition in a mouse transverse aortic arch banding model?
Does increased pulsatile pressure and flow alter arterial wall morphology and composition in a mouse transverse aortic arch banding model?
Pulsatile pressure and flow are critical stimuli for three-dimensional arterial adaptations, highlighting the importance of pulsatility in hypertensive carotid artery remodeling.
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Pulse pressure may drive carotid wall thickening more than mean pressure in this model; hypothesis-generating for pulsatility-targeted remodeling studies.
Eberth et al. (2009) studied this question.
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