Population
Freshly excised canine carotid arteries in vitro
Comparison
Pulsatile hemodynamic simulations including… vs Sham controls and normotension control values
Design
Preclinical
Follow-up
2-24 hours
Authors
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Animal data link pulse pressure/flow to endothelial cholesterol uptake; leaves open relevance to human hypertension or atherosclerosis.
Biomechanical stresses from altered hemodynamics, specifically increased pulse pressure and flow, significantly increase arterial cholesterol uptake and alter endothelial actin cytoskeleton, suggesting a mechanism for vascular disease.
Herman et al. (1987) studied this question.
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